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KMID : 0381219750070050283
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Journal of RIMSK
1975 Volume.7 No. 5 p.283 ~ p.300
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Ultrastructure of the Normal and Pathological Renal Glomerulus
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Abstract
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This is a review on the ultrastructure of the renal corpuscles in both the normal and abnormal conditions, and take several diseases as examples for the fine structural changes.
The parietal epithelium of Bowman´s capsule is composed of thin squamous cells, underlying relatively thick basement membrane, and the cells of the visceral layer, highly differentiated into podocytes whose foot processes anchor on the external side of capillary basement membrane. The filtration slit membrane crossing over the filtration slit between foot processes are resolved. The capillary basement membrane has three distinct layers: they are lamina rara externa, lamina densa, and lamina rara interna. The capillary endothelium is extremely attenuated and has numerous large pores with or without diaphragm and red blood cells in its lumen. The intraglomerular mesangium is connected with the extraglomerular which is a component of the juxtaglomerular complex. It is composed of mesangial cells and a few amount of mesangial matrix which has no direct contact with capillary lumen and covered also by the basement membrane.
The fine structural changes in pathological condition may be summarized as follows:
1. The fusion of foot processes of the podocytes.
2. The thickening of the glomerular basement membrane, mainly lamina densa.
3. ´The edematous swelling of endothelium and mesangial proliferation leading to capillary obliteration.
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KEYWORD
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